Genetic risk score for coronary artery calcification and its predictive ability for coronary artery disease.

ABSTRACT:

Aim

The modest added predictive value of the existing genetic risk scores (GRSs) for coronary artery disease (CAD) could be partly due to missing genetic components, hidden in the genetic architecture of intermediate phenotypes such as coronary artery calcification (CAC). In this study, we investigated the predictive ability of CAC GRS for CAD.

Materials and methods

We investigated the association of CAC GRSs with CAD and coronary calcification among the participants in the Ludwigshafen Risk and Cardiovascular Health study (LURIC) (n = 2742), the Tampere Vascular Study (TVS) (n = 133), and the Tampere Sudden Death Study (TSDS) (n = 660) using summary data from the largest multi-ancestry GWAS meta-analysis of CAC to date. Added predictive value of the CAC

SUBMITTER: Mishra PP 

PROVIDER: S-EPMC11525111 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature