Sustainable production of the drug precursor tyramine by engineered Corynebacterium glutamicum.

ABSTRACT: Tyramine has attracted considerable interest due to recent findings that it is an excellent starting material for the production of high-performance thermoplastics and hydrogels. Furthermore, tyramine is a precursor of a diversity of pharmaceutically relevant compounds, contributing to its growing importance. Given the limitations of chemical synthesis, including lack of selectivity and laborious processes with harsh conditions, the biosynthesis of tyramine by decarboxylation of L-tyrosine represents a promising sustainable alternative. In this study, the de novo production of tyramine from simple nitrogen and sustainable carbon sources was successfully established by metabolic engineering of the L-tyrosine overproducing Corynebacterium glutamicum strain AROM3. A phylogenetic analysis of a

SUBMITTER: Poethe SS 

PROVIDER: S-EPMC11525245 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature