Modelling Drug Delivery to the Small Airways: Optimization Using Response Surface Methodology.

ABSTRACT:

Aim

The aim of this in silico study was to investigate the effect of particle size, flow rate, and tidal volume on drug targeting to small airways in patients with mild COPD.

Method

Design of Experiments (DoE) was used with an in silico whole lung particle deposition model for bolus administration to investigate whether controlling inhalation can improve drug delivery to the small conducting airways. The range of particle aerodynamic diameters studied was 0.4 - 10 µm for flow rates between 100 - 2000 mL/s (i.e., low to very high), and tidal volumes between 40 - 1500 mL.

Results

The model accurately predicted the relationship between independent variables and lung deposition, as confirmed by comparison with published experimental data. It was found that large particles

SUBMITTER: Min HJ 

PROVIDER: S-EPMC11525259 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature