Distributed associations among white matter hyperintensities and structural brain networks with fluid cognition in healthy aging.

ABSTRACT: White matter hyperintensities (WMHs) are associated with age-related cognitive impairment and increased risk of Alzheimer's disease. However, the manner by which WMHs contribute to cognitive impairment is unclear. Using a combination of predictive modeling and network neuroscience, we investigated the relationship between structural white matter connectivity and age, fluid cognition, and WMHs in 68 healthy adults (18-78 years). Consistent with previous work, WMHs were increased in older adults and exhibited a strong negative association with fluid cognition. Extending previous work, using predictive modeling, we demonstrated that age, WMHs, and fluid cognition were jointly associated with widespread alterations in structural connectivity. Subcortical-cortical connections between the thalam

SUBMITTER: Rudolph MD 

PROVIDER: S-EPMC11525275 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature