Prostate cancer lesions in transition zone exhibit a higher propensity for pathological upgrading in radical prostatectomy.

ABSTRACT:

Background

The varying malignancy and lethality of different grades of prostate cancer (PCa) highlight the importance of accurate diagnosis. This study aims to evaluate the upgrading of transition zone (TZ) prostate cancer biopsies and identify factors to improve TZ biopsy accuracy.

Materials and methods

This retrospective study included 217 patients who underwent laparoscopic radical prostatectomy after 12 + X cores transperineal transrectal ultrasound-magnetic resonance imaging (MRI)-guided targeted prostate biopsy from 2018 to 2021 in our center.

Results

Patients with TZ lesions showed a higher incidence of International Society of Urological Pathology (ISUP) grade upgrading from 1 to higher grade compared to peripheral zone lesions (16.9% vs. 5.0%, p = 0.005). Mul

SUBMITTER: Chen X 

PROVIDER: S-EPMC11525276 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature