Amide proton transfer-weighted CEST MRI for radiotherapy target delineation of glioblastoma: a prospective pilot study.

ABSTRACT:

Background

Extensive glioblastoma infiltration justifies a 15-mm margin around the gross tumor volume (GTV) to define the radiotherapy clinical target volume (CTV). Amide proton transfer (APT)-weighted imaging could enable visualization of tumor infiltration, allowing more accurate GTV delineation. We quantified the impact of integrating APT-weighted imaging into GTV delineation of glioblastoma and compared two APT-weighted quantification methods-magnetization transfer ratio asymmetry (MTR_asym) and Lorentzian difference (LD) analysis-for target delineation.

Methods

Nine glioblastoma patients underwent an extended imaging protocol prior to radiotherapy, yielding APT-weighted MTR_asym and LD maps. From both maps, biological tumor volumes were generated (BT

SUBMITTER: Tang PLY 

PROVIDER: S-EPMC11525355 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature