Short-term gut microbiota's shift after laparoscopic Roux-en-Y vs one anastomosis gastric bypass: results of a multicenter randomized control trial.

ABSTRACT:

Background

Roux-en-Y (RYGB) and one anastomosis gastric bypass (OAGB) represent two of the most used bariatric/metabolic surgery (BMS) procedures. Gut microbiota (GM) shift after bypass surgeries, currently understated, may be a possible key driver for the short- and long-term outcomes.

Methods

Prospective, multicenter study enrolling patients with severe obesity, randomized between OAGB or RYGB. Fecal and blood samples were collected, pre- (T0) and 24 months postoperatively (T1). GM was determined by V3-V4 16S rRNA regions sequencing and home-made bioinformatic pipeline based on Qiime2 plugin and R packages.

Objects

To compare OAGB vs RYGB microbiota profile at T1 and its impact on metabolic and nutritional status.

Results

54 patients completed the study, 27 f

SUBMITTER: De Maio F 

PROVIDER: S-EPMC11525425 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature