Dynamics of minimal residual disease and its clinical implications in multiple myeloma: A retrospective real-life analysis.

ABSTRACT:

Background

Minimal residual disease (MRD) testing is a promising approach to tailor the treatment of multiple myeloma (MM). However, several major concerns remain to be addressed before moving it into daily practice, most of which stem from the dynamic nature of the MRD status. Thus, it is crucial to understand the MRD dynamics and propose its clinical implications.

Methods

We retrospectively analysed the data of patients with newly diagnosed MM (NDMM) who had flow cytometry-based MRD tests at multiple time points after initiation of therapy. The impact of undetectable MRD (including attainment, duration and loss) on clinical outcomes was analysed.

Results

In a cohort of 220 patients with NDMM, attainment of MRD^- offered favourable outcomes (P < 0.0001 for

SUBMITTER: Xu W 

PROVIDER: S-EPMC11525448 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature