The myocardial function index (MFI): An integrated measure of cardiac function in AL-cardiomyopathy.

ABSTRACT:

Background

Amyloid light chain (AL) amyloidosis is a systemic disease that can cause restrictive cardiomyopathy (AL-CM). Current imaging techniques are not sensitive to detect myocardial dysfunction in AL-CM. We sought to evaluate role of a novel marker of myocardial dysfunction (myocardial function index, MFI) obtained using changes in left ventricular (LV) blood pool and myocardial volume in diastole and systole.

Methods

Consecutive patients diagnosed with AL-CM who had underwent cardiac MRI between 2001-2017 were identified and compared to healthy individuals. Two independent operators used cardiac MRI to perform epicardial and endocardial tracings in systole and diastole to obtain myocardial volume in diastole (MVd) and myocardial volume in systole (MVs). Changes in myoc

SUBMITTER: Akhiyat N 

PROVIDER: S-EPMC11525457 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature