Non-invasive assessment of programmed cell death ligand-1 expression using ¹⁸F-FDG PET-CT imaging in esophageal squamous cell carcinoma.

ABSTRACT: Programmed cell death ligand-1 (PD-L1) is an ideal checkpoint for immunohistochemical detection. The method of obtaining PD-L1 expression through biopsy can impact the accurate assessment of PD-L1 expression due to the spatial and temporal heterogeneity of tumors. Because of the limited sample size, biopsies often give only a localized picture of the tumor. In this retrospective study, a total of 2,386 metabolic tumor volume (MTV) features were extracted from ¹⁸F-FDG PET-CT images. A radiomics model was developed to holistically and non-invasively assess PD-L1 expression in patients with esophageal squamous cell carcinoma by identifying seven independent factors through feature screening. The radiomics model shows effective discrimination, with an area under the receiver operati

SUBMITTER: Miao L 

PROVIDER: S-EPMC11525474 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature