Exploring the role of different cell types on cortical folding in the developing human brain through computational modeling.

ABSTRACT: The human brain's distinctive folding pattern has attracted the attention of researchers from different fields. Neuroscientists have provided insights into the role of four fundamental cell types crucial during embryonic development: radial glial cells, intermediate progenitor cells, outer radial glial cells, and neurons. Understanding the mechanisms by which these cell types influence the number of cortical neurons and the emerging cortical folding pattern necessitates accounting for the mechanical forces that drive the cortical folding process. Our research aims to explore the correlation between biological processes and mechanical forces through computational modeling. We introduce cell-density fields, characterized by a system of advection-diffusion equations, designed to replicate the

SUBMITTER: Zarzor MS 

PROVIDER: S-EPMC11525573 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature