Adverse effects of CXCR2 deficiency in mice reared under non-gnotobiotic conditions.

ABSTRACT: The family of pro-inflammatory and pro-angiogenic chemokines including Interleukin-8 (IL-8, aka CXCL8) and its homologues (CXCL1,2,3,5,6, and 7) exhibit promiscuous binding and activation of several G-protein-coupled receptors (i.e., CXCR2, CXCR1, and the atypical chemokine receptor (ACKR1)). A high proportion of their biological activity is attributed to CXCR2 activation, thus many CXCR2 inhibitors are in clinical trials for several chronic diseases. However, CXCR2 inhibition is often only investigated acutely in these trials or in Cxcr2^-/- mice grown in gnotobiotic conditions. Since humans do not live in germ-free environments, our first goal is to highlight novel retinal and systemic observations in Cxcr2^-/- mice grown in non-gnotobiotic conditions that suggest pot

SUBMITTER: Garcia MJ 

PROVIDER: S-EPMC11525579 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature