A large scale multi institutional study for radiomics driven machine learning for meningioma grading.

ABSTRACT: This study aims to develop and evaluate radiomics-based machine learning (ML) models for predicting meningioma grades using multiparametric magnetic resonance imaging (MRI). The study utilized the BraTS-MEN dataset's training split, including 698 patients (524 with grade 1 and 174 with grade 2-3 meningiomas). We extracted 4872 radiomic features from T1, T1 with contrast, T2, and FLAIR MRI sequences using PyRadiomics. LASSO regression reduced features to 176. The data was split into training (60%), validation (20%), and test (20%) sets. Five ML algorithms (TabPFN, XGBoost, LightGBM, CatBoost, and Random Forest) were employed to build models differentiating low-grade (grade 1) from high-grade (grade 2-3) meningiomas. Hyperparameter tuning was performed using Optuna, optimizing model-specific

SUBMITTER: Karabacak M 

PROVIDER: S-EPMC11525589 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature