Acceleration of Brain Atrophy and Progression From Normal Cognition to Mild Cognitive Impairment.

ABSTRACT:

Importance

It remains unclear which risk factors accelerate brain atrophy along with a progression from normal cognition to mild cognitive impairment (MCI).

Objective

To examine risk factors associated with the acceleration of brain atrophy and progression from normal cognition to MCI based on long-term longitudinal data for middle-aged and older adults.

Design, setting, and participants

Data for this cohort study were extracted from the Biomarkers for Older Controls at Risk for Dementia (BIOCARD) cohort, initiated at the National Institutes of Health from January 1, 1995, to December 31, 2005, and continued at Johns Hopkins University from January 1, 2015, to October 31, 2023. All participants were cognitively normal at baseline. The participants whose structural mag

SUBMITTER: Uchida Y 

PROVIDER: S-EPMC11525609 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature