Impact of T-2 toxin on intestinal inflammation and transcriptional regulation of inflammatory response in mouse macrophages.

ABSTRACT: T-2 toxin, a fungal secondary metabolite produced by toxigenic Fusarium species, poses a significant threat to grain food and feed due to its potential to cause intestinal inflammation in livestock and poultry. Macrophages play a crucial role as integral components of the body's immune system during intestinal inflammation. This study aimed to elucidate the mechanism behind the inflammatory response triggered by T-2 toxin in macrophages. Compared to the control group, gavage administration of T-2 toxin (0.33, 1, and 4 mg kg^-1) led to a decrease in body weight and feed intake, along with histopathological alterations in the colon of mice. In addition, T-2 toxin induced the upregulation of macrophage-derived cytokines like IL-1β, IL-6, and TNF-α, as well as a rise in the po

SUBMITTER: Yang X 

PROVIDER: S-EPMC11525619 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature