Decoding marker genes and immune landscape of unstable carotid plaques from cellular senescence.

ABSTRACT: Recently, cellular senescence-induced unstable carotid plaques have gained increasing attention. In this study, we utilized bioinformatics and machine learning methods to investigate the correlation between cellular senescence and the pathological mechanisms of unstable carotid plaques. Our aim was to elucidate the causes of unstable carotid plaque progression and identify new therapeutic strategies. First, differential expression analysis was performed on the test set GSE43292 to identify differentially expressed genes (DEGs) between the unstable plaque group and the control group. These DEGs were intersected with cellular senescence-associated genes to obtain 40 cellular senescence-associated DEGs. Subsequently, key genes were then identified through weighted gene co-expression network a

SUBMITTER: Cai GF 

PROVIDER: S-EPMC11525637 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature