Investigating the causal association between serum uric acid levels and gastric cancer risk: a Mendelian randomization study.

ABSTRACT: The causal link between serum uric acid (SUA) levels and gastric cancer susceptibility remains inadequately elucidated. This investigation employed a two-sample Mendelian randomization (MR) framework to assess the potential causative link between SUA concentrations and the propensity for developing gastric cancer. To further explore potential racial differences, this MR analysis was conducted on cohorts of both European and East Asian descent. Data from a large-scale GWAS in 343,836 Europeans and 92,615 East Asians were screened for 206 and 45 SNPs significantly linked to SUA levels, respectively, as genetic variants. Subsequently, four distinct MR methodologies were deployed to determine how SUA levels affected gastric cancer risk. Using the fixed-effects IVW approach, our analysis reveal

SUBMITTER: Zhao X 

PROVIDER: S-EPMC11525654 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature