Altered brain complexity in first-episode antipsychotic-naive patients with schizophrenia: A whole-brain voxel-wise study.

ABSTRACT:

Background

Measures of cortical topology are believed to characterize large-scale cortical networks. Previous studies used region of interest (ROI)-based approaches with predefined templates that limit analyses to linear pair-wise interactions between regions. As cortical topology is inherently complex, a non-linear dynamic model that measures the brain complexity at the voxel level is suggested to characterize topological complexities of brain regions and cortical folding.

Methods

T1-weighted brain images of 150 first-episode antipsychotic-naïve schizophrenia (FES) patients and 161 healthy comparison participants (HC) were examined. The Chaos analysis approach was applied to detect alterations in brain structural complexity using the largest Lyapunov exponent (Lambda) as th

SUBMITTER: Liu N 

PROVIDER: S-EPMC11525771 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature