Small gold nanoparticles for tandem cyclization/reduction and cyclization/hydroalkoxylation reactions.

ABSTRACT: With peculiar structural features at the surface of small metal nanoparticles, some discrete sites can display catalytic behaviour similar to what could be observed with mononuclear metal catalysts in solution. We have studied the transfer of two catalytic tandem reactions from homogeneous to heterogeneous conditions. Tandem cyclisation/reduction of ortho-alkynyl benzaldehyde derivatives was successfully achieved with Au nanoparticles over TiO₂ (Au NPs/TiO₂) in the presence of Hantzsch ester with 45-98% yields for 15 examples (average yield: 70.4%). Similarly, tandem cyclisation/hydroalkoxylation of ortho-alkynyl benzaldehyde derivatives was successfully achieved with Au NPs/TiO₂ in methanol or other alcohols with 62-96% yields for 17 examples (average yiel

SUBMITTER: Plevova K 

PROVIDER: S-EPMC11525795 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature