Stage dependent microbial dynamics in hepatocellular carcinoma and adjacent normal liver tissues.

ABSTRACT: The interactive pathway of the gut-liver axis underscores the significance of microbiome modulation in the pathogenesis and progression of various liver diseases, including hepatocellular carcinoma (HCC). This study aims to investigate the disparities in the composition and functionality of the hepatic microbiota between tumor tissues and adjacent normal liver tissues, and their implications in the etiology of HCC. We conducted a comparative analysis of the hepatic microbiome between adjacent normal liver tissues and tumor tissues from HCC patients. Samples were categorized according to the modified Union for International Cancer Control (mUICC) staging system into Non-tumor, mUICC stage I, mUICC stage II, and mUICC stage III groups. Microbial richness and community composition were analyz

SUBMITTER: Jo HE 

PROVIDER: S-EPMC11525880 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature