Exploring the potential role of microbiota and metabolites in acute exacerbation of chronic obstructive pulmonary disease.

ABSTRACT: The acute exacerbation of chronic obstructive pulmonary disease seriously affects the respiratory system function and quality of life of patients. This study employed 16S rRNA sequencing and metabolomics techniques to analyze the respiratory microbiota and serum metabolites of COPD and AECOPD patients. The results showed that the microbial diversity in the respiratory tract of AECOPD patients was significantly lower than that of COPD patients, and the relative abundance of Bacteroidetes, Prevotella and Neisseria in the respiratory tract of AECOPD patients was significantly lower than that of COPD patients. However, the relative abundance of Haemophilus_D, Veillonella_A and Pseudomonas_E, in AECOPD patients was significantly higher than that of COPD patien

SUBMITTER: Shi Y 

PROVIDER: S-EPMC11526122 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature