Azo derivatives of monoterpenes as anti-Helicobacter pylori agents: from synthesis to structure-based target investigation.

ABSTRACT: Helicobacter pylori (Hp) infection affects nearly half of the global population. Current therapeutic options include the administration of a combination of antibiotics and proton pump inhibitors, although antimicrobial resistance rise remains a big concern. Phenolic monoterpenes, e.g., eugenol, vanillin, carvacrol, and thymol, have always attracted researchers for their multifaced biological activities and the possibility to be easily derivatized. Thereby, herein we present the functionalization of such compounds through the conventional aryl diazotization reaction, generating a series of mono- and bis-azo derivatives (1-28). Also, to continue previous studies, we investigated the role of the free phenolic moiety of thymol with eight compounds (29-36). The compounds we

SUBMITTER: Melfi F 

PROVIDER: S-EPMC11526209 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature