ENO1 as a Biomarker of Breast Cancer Progression and Metastasis: A Bioinformatic Approach Using Available Databases.

ABSTRACT:

Background

Metabolic reprogramming is one of the hallmarks of cancer, and in breast cancer (BC), several metabolic enzymes are overexpressed and overactivated. One of these, Enolase 1 (ENO1), catalyses glycolysis and is involved in the regulation of multiple signalling pathways.

Objectives

This study aimed to evaluate in silico the prognostic and predictive effects of ENO1 expression in BC.

Design

This is a bioinformatic in silico analysis.

Methods

Using available online platforms (Kaplan-Meier [KM] plotter, receiver operating characteristic curve [ROC] plotter, cBioPortal, Genotype-2-Outcome [G-2-O], MethSurv, and Tumour-Immune System Interaction Database [TISIDB]), we performed a bioinformatic in silico analysis to establish the prognostic and predictive effe

SUBMITTER: Giannoudis A 

PROVIDER: S-EPMC11526306 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature