Multiple-Criteria Decision Analysis for Assessments of Chemical Alternatives (MCDA-ACA).

ABSTRACT: A comprehensive assessment of chemical alternatives (ACA) is necessary to avoid regrettable substitution. In a preceding study, an analysis of six hazard assessment methods found that none of them are fully aligned with the hazard assessment criteria of Article 57 of the European REACH regulation, indicating a need for a method better reflecting hazard assessment schemes in European chemical regulations. This paper presents a multiple-criteria decision analysis (MCDA) method for the ACA that takes the criteria of Article 57 of REACH into account. Investigated and presented are objective hierarchies, the aggregation of objectives, the curvature of the value functions, weights, and the introduction of a classification threshold. The MCDA-ACA method allows for the aggregation of hazards in su

SUBMITTER: London RL 

PROVIDER: S-EPMC11526351 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature