Causal linkage of Graves' disease with aging: Mendelian randomization analysis of telomere length and age-related phenotypes.

ABSTRACT:

Background

Aging is an irreversible progressive decline in physical function. Graves' disease (GD) is a common cause of hyperthyroidism and is characterized by elevated levels of the thyroid hormone (TH). High TH levels are associated with aging and a shortened lifespan. The causal relationship between GD and aging has yet to be investigated.

Methods

We used genome-wide association study (GWAS) datasets and Mendelian randomization (MR) analysis to explore the causal link between GD and aging. To assess the statistical power of instrumental variables (IVs), F-statistics and R² were used. MR analysis was conducted using inverse-variance weighting (IVW), MR-Egger, weighted median, and weighted mode. The odds ratio (OR) and 95% CI were calculated to estimate the relat

SUBMITTER: Hu J 

PROVIDER: S-EPMC11526548 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature