TM9SF1 expression correlates with autoimmune disease activity and regulates antibody production through mTOR-dependent autophagy.

ABSTRACT:

Background

Transmembrane 9 superfamily member 1 (TM9SF1) is involved in inflammation. Since both inflammatory and autoimmune diseases are linked to immune cells regulation, this study investigated the association between TM9SF1 expression and autoimmune disease activity. As B cell differentiation and autoantibody production exacerbate autoimmune disease, the signaling pathways involved in these processes were explored.

Methods

Tm9sf1^-/- mouse rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE) models were used to verify the relationship between gene expression and disease severity. Peripheral blood mononuclear cells (PBMCs) from 156 RA and 145 SLE patients were used to explore the relationship between TM9SF1 expression and disease activity. The effect

SUBMITTER: Xiao J 

PROVIDER: S-EPMC11526568 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature