Effect of breathing phase number on the 4D robust optimization for pancreatic cancer intensity modulated proton therapy.

ABSTRACT:

Purpose

Respiratory movement, as one of the main challenges in proton therapy for pancreatic cancer patients, could not only lead to harm to normal tissues but also lead to failure of the tumor control, resulting in irreversible consequences. Including respiratory movements into the plan optimization, i.e. 4D robust optimization, may mitigate the interplay effect. However, 4D robust optimization considering images of all breathing phases is time-consuming and less efficient. This work aims to investigate the effect of the breathing phase number on the 4D robust optimization for pancreatic cancer intensity modulated proton therapy (IMPT) by examining plan quality and computational efficiency.

Methods

A total of 15 pancreatic cancer patients were retrospectively analyzed. In t

SUBMITTER: Fan X 

PROVIDER: S-EPMC11526620 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature