Quantitative proteomic profiling reveals sexual dimorphism in the retina and RPE of C57BL6 mice.

ABSTRACT:

Background

Sex as a biological variable is not a common consideration in molecular mechanistic or preclinical studies of retinal diseases. Understanding the sexual dimorphism of adult RPE and retina under physiological conditions is an important first step in improving our understanding of sex-based physio-pathological mechanisms.

Methods

Isobaric tags for relative and absolute quantitation (iTRAQ) were used for quantitative proteomics of male and female mouse retina and RPE (10 mice of each sex for each tissue type). Differentially expressed proteins were subjected to Gene Ontology (GO) analysis and Ingenuity Pathway Analysis (IPA).

Results

Differential expression analysis identified 21 differentially expressed proteins in the retina and 58 differentially expressed p

SUBMITTER: Jang GF 

PROVIDER: S-EPMC11526624 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature