Causal relationship between hypothyroidism and ulcerative colitis: a bidirectional Mendelian randomization study.

ABSTRACT:

Objective

Ulcerative colitis (UC) and Hashimoto's thyroiditis frequently cooccur in patients with multiple autoimmune conditions, but the specific association between UC and hypothyroidism is unknown. We used Mendelian randomization (MR) methods to determine the causal relationship between UC and hypothyroidism.

Methods

We obtained single nucleotide polymorphisms (SNPs) related to ulcerative colitis (UC) and hypothyroidism from genome-wide association studies (GWAS) available in the public database of the Integrated Epidemiology Unit (IEU). To assess the causal relationship between UC and hypothyroidism, we employed MR-Egger, weighted median, inverse variance weighted (IVW), simple mode, and weighted mode methods. Sensitivity analyses were performed using Cochran's Q test, t

SUBMITTER: Yang Y 

PROVIDER: S-EPMC11526713 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature