Genotypic Diversity among <i>Salmonella</i> Typhi Isolated from Children Living in Informal Settlements in Nairobi, Kenya.

ABSTRACT: The persistence of multidrug-resistant (MDR) Salmonella Typhi (S. Typhi) is a challenge especially in regions where typhoid is endemic. Surveillance of circulating genotypes of MDR S. Typhi is crucial in typhoid acute cases and carriers. This study aimed to investigate genotypic diversity of S. Typhi from symptomatic and asymptomatic children in endemic settings in Nairobi, Kenya. Symptomatic and asymptomatic individuals' ≤ 16 years were recruited at four health facilities and tested for typhoid through stool cultures. The S. Typhi isolates were subjected to antibiotic susceptibility testing to investigate multidrug resistance. The MDR S. Typhi isolates' DNA was extracted and illumina sequenced. Raw reads were de novo assembled and analyzed

SUBMITTER: Kavai SM 

PROVIDER: S-EPMC11526766 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature