Probiotic therapy modulates the brain-gut-liver microbiota axis in a mouse model of traumatic brain injury.

ABSTRACT: The interplay between gut microbiota and host health is crucial for maintaining the overall health of the body and brain, and it is even more crucial how changes in the bacterial profile can influence the aftermath of traumatic brain injury (TBI). We studied the effects of probiotic treatment after TBI to identify potential changes in hepatic lipid species relevant to brain function. Bioinformatic analysis of the gut microbiota indicated a significant increase in the Firmicutes/Bacteroidetes ratio in the probiotic-treated TBI group compared to sham and untreated TBI groups. Although strong correlations between gut bacteria and hepatic lipids were found in sham mice, TBI disrupted these links, and probiotic treatment did not fully restore them. Probiotic treatment influenced systemic glucos

SUBMITTER: Amaral WZ 

PROVIDER: S-EPMC11526848 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature