Hybrid incompatibility emerges at the one-cell stage in interspecies <i>Caenorhabditis</i> embryos.

ABSTRACT: Intrinsic reproductive isolation occurs when genetic divergence between populations disrupts hybrid development, preventing gene flow and enforcing speciation.^1-4 Over the past two decades, researchers have identified molecular mechanisms underlying a few dozen cases of hybrid incompatibility in animals.⁵ Much of this work has focused on mismatches in zygotic gene regulation,^6-11 but other mechanisms have also emerged, including symbiont-driven incompatibilities,¹² nucleoporin mismatches affecting nuclear-cytoplasmic transport,¹³ and divergence in centromeric or heterochromatic regions and their regulatory proteins which can lead to the inability of the oocyte cytoplasm to segregate sperm-derived chromosomes.^14-19 Since stud

SUBMITTER: Bloom J 

PROVIDER: S-EPMC11526918 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature