Protein catabolites as blood-based biomarkers of aging physiology: Findings from the Dog Aging Project.

ABSTRACT: Our understanding of age-related physiology and metabolism has grown through the study of systems biology, including transcriptomics, single-cell analysis, proteomics and metabolomics. Studies in lab organisms in controlled environments, while powerful and complex, fall short of capturing the breadth of genetic and environmental variation in nature. Thus, there is now a major effort in geroscience to identify aging biomarkers and to develop aging interventions that might be applied across the diversity of humans and other free-living species. To meet this challenge, the Dog Aging Project (DAP) is designed to identify cross-sectional and longitudinal patterns of aging in complex systems, and how these are shaped by the diversity of genetic and environmental variation among companion dogs. H

SUBMITTER: Harrison BR 

PROVIDER: S-EPMC11526923 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature