Site of breast cancer metastasis is independent of single nutrient levels.

ABSTRACT: Cancer metastasis is a major contributor to patient morbidity and mortality¹, yet the factors that determine the organs where cancers can metastasize are incompletely understood. In this study, we quantify the absolute levels of over 100 nutrients available across multiple tissues in mice and investigate how this relates to the ability of breast cancer cells to grow in different organs. We engineered breast cancer cells with broad metastatic potential to be auxotrophic for specific nutrients and assessed their ability to colonize different organs. We then asked how tumor growth in different tissues relates to nutrient availability and tumor biosynthetic activity. We find that single nutrients alone do not define the sites where breast cancer cells can grow as metastases. Additio

SUBMITTER: Abbott KL 

PROVIDER: S-EPMC11527034 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature