Increased Insular Functional Connectivity During Repetitive Negative Thinking in Major Depression and Healthy Volunteers.

ABSTRACT:

Background

Repetitive negative thinking (RNT) in major depressive disorder (MDD) involves persistent focus on negative self-related experiences. Resting-state fMRI shows that the functional connectivity (FC) between the insula and the superior temporal sulcus is critical to RNT intensity. This study examines how insular FC patterns differ between resting-state and RNT-induction in MDD and healthy participants (HC).

Methods

Forty-one individuals with MDD and twenty-eight HCs (total n=69) underwent resting-state and RNT-induction fMRI scans. Seed-to-whole brain analysis using insular subregions as seeds was performed.

Results

No diagnosis-by-run interaction effects were observed across insular subregions. MDD participants showed greater FC between bilateral anterior, mi

SUBMITTER: Edwards LS 

PROVIDER: S-EPMC11527064 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature