Shared and unique lifetime stressor characteristics and network connectivity predict adolescent anxiety and depression.

ABSTRACT:

Background

Exposure to major life stressors and aberrant brain functioning have been related to anxiety and depression, especially during adolescence. However, whether these associations differ based on the specific characteristics of the stressors experienced, and/or the functional networks engaged, remains unclear.

Methods

We used baseline lifetime stressor exposure and resting-state functional magnetic resonance imaging data from a longitudinal sample of 150 adolescents enriched for anxiety and depressive disorders. We examined the cumulative lifetime stressor frequency and severity of five stressor characteristics: physical danger, interpersonal loss, humiliation, entrapment, and role change/disruption. Anxiety and depression symptoms were assessed at three time points:

SUBMITTER: Qu YL 

PROVIDER: S-EPMC11527110 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature