Improved protein interaction models predict differences in complexes between human cell lines.

ABSTRACT: The interactions of proteins to form complexes play a crucial role in cell function. Data on protein-protein or pairwise interactions (PPI) typically come from a combination of sample separation and mass spectrometry. Since 2010, several extensive, high-throughput mass spectrometry-based experimental studies have dramatically expanded public repositories for PPI data and, by extension, our knowledge of protein complexes. Unfortunately, challenges of limited overlap between experiments, modality-oriented biases, and prohibitive costs of experimental reproducibility continue to limit coverage of the human protein assembly map, both underscoring the need for and spurring the development of relevant computational approaches. Here, we present a new method for predicting the strength of protein

SUBMITTER: Wilkins GR 

PROVIDER: S-EPMC11527118 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature