A multichannel electrophysiological approach to noninvasively and precisely record human spinal cord activity.

ABSTRACT: The spinal cord is of fundamental importance for integrative processing in brain-body communication, yet routine noninvasive recordings in humans are hindered by vast methodological challenges. Here, we overcome these challenges by developing an easy-to-use electrophysiological approach based on high-density multichannel spinal recordings combined with multivariate spatial-filtering analyses. These advances enable a spatiotemporal characterization of spinal cord responses and demonstrate a sensitivity that permits assessing even single-trial responses. To furthermore enable the study of integrative processing along the neural processing hierarchy in somatosensation, we expand this approach by simultaneous peripheral, spinal, and cortical recordings and provide direct evidence that bottom-u

SUBMITTER: Nierula B 

PROVIDER: S-EPMC11527246 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature