Impact of sample processing delays on plasma markers of inflammation, chemotaxis, cell death, and blood coagulation.

ABSTRACT:

Background

Biosampling studies in critically ill patients traditionally involve bedside collection of samples followed by local processing (ie. centrifugation, aliquotting, and freezing) and storage. However, community hospitals, which care for the majority of Canadian patients, often lack the infrastructure for local processing and storage of specimens. A potential solution is a "simplified" biosampling protocol whereby blood samples are collected at the bedside and then shipped to a central site for processing and storage. One potential limitation of this approach is that delayed processing may alter sample characteristics.

Objective

To determine whether delays in blood sample processing affect the stability of cytokines (IL-6, TNF, IL-10, IFN-γ), chemokines (IL-8, IP-10,

SUBMITTER: Gyorffy VJ 

PROVIDER: S-EPMC11527306 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature