A universal hippocampal memory code across animals and environments.

ABSTRACT: How learning generalizes across contexts is a fundamental question in neuroscience, with broad implications for adaptive behavior and cognition. The hippocampus (HPC) plays a key role in contextual learning, but HPC cells exhibit place-specific activity that reorganizes, or 'remaps' across environments, raising the question of how stable, task-relevant representations can be preserved. Here, we used calcium imaging to monitor hippocampal neuron activity as rats performed a conditioning task across multiple spatial contexts. We asked whether hippocampal neurons, which encode both spatial locations and task-relevant features, could maintain stable representations of the task despite remapping of spatial codes. To assess representational consistency, we applied dimensionality reduction and ma

SUBMITTER: Wirtshafter HS 

PROVIDER: S-EPMC11527332 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature