Suspected Postpartum Depression Revealed to be CSF1R-Related Leukoencephalopathy: A Case Report.

ABSTRACT:

Introduction

This is a case of a 32-year-old woman who developed postpartum depression (PPD). She became anxious and depressive about caring for her child, and the Edinburgh Postnatal Depression Scale (EPDS) test showed a score of 9 at 2 weeks after delivery, and at 7 months postpartum, she presented with major melancholic depression followed by mild cognitive decline without any neurological symptoms except cluttering speech.

Case presentation

Cerebral magnetic resonance imaging showed confluent fluid-attenuated inversion recovery hyperintensities in the periventricular and frontal deep white matter, with multiple spotty calcifications in the frontal white matter by cerebral CT. Genetic testing revealed a mutation in the colony-stimulating factor 1 receptor (CSF1R).

Conc

SUBMITTER: Mikuni M 

PROVIDER: S-EPMC11527462 | biostudies-literature | 2024 Jan-Dec

REPOSITORIES: biostudies-literature