The impact of atrial fibrillation on clinical outcomes in heart failure with mid-range and preserved ejection fraction patients.

ABSTRACT:

Background

The combined effect of left ventricular ejection fraction (LVEF) and atrial fibrillation (AF) on clinical outcomes in heart failure (HF) remains complex.

Objective

In this post hoc analysis of the TOPCAT trial, we aimed to evaluate the impact of AF on clinical outcomes in patients with HF stratified by LVEF range.

Methods

A total of 3442 patients were included, stratified into 3 groups according to LVEF range-HF with mid-range ejection fraction (HFmrEF), LVEF of 45%-50% (n = 823); HF with preserved ejection fraction (HFpEF), LVEF of 51%-60% (n = 1682); and HF with normal ejection fraction (HFnEF), LVEF >60% (n = 937)-and subdivided according to the presence of AF at enrollment. Cox regression analysis was used to define independent associations between AF a

SUBMITTER: Mustafina I 

PROVIDER: S-EPMC11527566 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature