Evidence of symptom specificity for depression in multiple sclerosis: A two sample Mendelian randomization study.

ABSTRACT:

Background

Depression is common and phenotypically heterogenous in multiple sclerosis (MS). MS may increase risk of some but not all affective symptoms or certain symptoms may predispose individuals to higher MS risk.

Objective

To assess the existence and direction of causality between distinct depressive symptoms and MS using two-sample Mendelian randomization (MR).

Methods

Using summary data from genome-wide association studies, we selected genetic instrument variables (IV) for MS (n = 115,776) and IVs for depressive symptoms (average n = 117,713): anhedonia, altered appetite, concentration, depressed mood, fatigue, inadequacy, psychomotor changes, sleeping problems and suicidality. We performed two-sample MR in either direction using inverse-variance models. Sensit

SUBMITTER: Hu C 

PROVIDER: S-EPMC11527576 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature