The effect of lipidomes on the risk of endometrioid endometrial cancer: a Mendelian randomization study.

ABSTRACT:

Objective

This study aimed to explore the potential effects between various human plasma lipidomes and endometrioid endometrial cancer (EEC) by using Mendelian randomization (MR) methods.

Methods

This study designated a total of 179 human plasma lipidomes from the genome-wide association study (GWAS) database as the exposure variable. An EEC-related dataset from the GWAS (GCST006465) served as the outcome variable. MR analyses used the inverse variance-weighted method (IVW), MR-Egger, weighted median, simple mode, and weighted mode methods for regression calculations, accounting for possible biases induced by linkage disequilibrium and weak instrument variables. Any lipidomes failing to pass heterogeneity and horizontal pleiotropy tests were deemed to lack significant causal

SUBMITTER: Lou Y 

PROVIDER: S-EPMC11527595 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature