NSG2: a promising prognostic marker shaping the immune landscape of breast cancer.

ABSTRACT:

Background

Breast cancer (BC) remains a significant health issue globally and most common cause of mortality in women. Enhancing our understanding on biomarkers may greatly improve both diagnostic and therapeutic approaches to this disease.

Methods

We retrospectively assessed tumor samples from 228 BC cases and 51 normal samples, alongside relevant clinical data. Neuronal vesicle trafficking associated 2(NSG2) expression was evaluated through bioinformatics and multiplex immunohistochemistry. Associations between NSG2 expression, tumor-infiltrating immune cells (TIICs), immune checkpoints, and clinical outcomes were investigated.

Results

NSG2 was present in both breast cancer cells and adjacent stromal cells. Increased NSG2 expression in cancer cells correlated with g

SUBMITTER: Li X 

PROVIDER: S-EPMC11527618 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature