Distribution diversity and expression regulation of class 1 integron promoters in clinical isolates of <i>Morganella morganii</i>.

ABSTRACT:

Background

Morganella morganii is an emerging nosocomial opportunistic pathogen with increasing multidrug resistance. Antibiotic resistance, driven primarily by the horizontal transfer of resistance genes, has become a global health crisis. Integrons, mobile genetic elements, are now understood to facilitate the transfer of these genes, contributing to the rapid proliferation of resistant strains. Understanding the regulatory role of integrons in drug resistance gene expression is crucial for developing novel strategies to combat this pressing public health issue.

Objective

To investigate the distribution of promoter types in the variable regions of class 1 integrons isolated from clinical isolates of M. morganii and their regulatory role in the expression of d

SUBMITTER: Yang Y 

PROVIDER: S-EPMC11527653 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature