Association of glymphatic system dysfunction with cognitive impairment in temporal lobe epilepsy.

ABSTRACT:

Objectives

To explore the relationship between glymphatic dysfunction and cognitive impairment in unilateral temporal lobe epilepsy (TLE).

Methods

This study retrospectively included 38 patients with unilateral TLE and 26 age- and gender-matched healthy controls (HCs). The diffusion tensor image analysis along the perivascular space (DTI-ALPS) index, choroid plexus volume (CPV), and cognitive assessment were obtained for each participant. Neuropsychological test batteries included Montreal Cognitive Assessment (MoCA), Minimum Mental State Examination, Arithmetic Test (AT), Digit Symbol Substitution Test (DSST), Digit Span Test (DST), Boston Naming Test, Block design, Phonological Fluency Test (PFT), and Semantic Verbal Fluency (SVF).

Results

Compared to HCs, TLE patie

SUBMITTER: Wang J 

PROVIDER: S-EPMC11527717 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature