Unveiling new protein biomarkers and therapeutic targets for acne through integrated analysis of human plasma proteomics and genomics.

ABSTRACT:

Background

The current landscape of acne therapeutics is notably lacking in targeted treatments, highlighting a critical need for the discovery of new drug targets to improve treatment outcomes.

Objectives

This study aims to investigate the connections between proteomics and genetics in relation to acne across extensive population cohorts, aspiring to identify innovative preventive and therapeutic approaches.

Methods

Employing a longitudinal cohort of 54,306 participants from the UK Biobank Pharmacological Proteomics Project (UKB-PPP), we performed an exhaustive evaluation of the associations between 2,923 serum proteins and acne risk. Initial multivariate Cox regression analyses assessed the relationship between protein expression levels and acne onset, followed by t

SUBMITTER: Deng S 

PROVIDER: S-EPMC11527721 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature