Causal association between cystatin C and diabetic retinopathy: A two-sample Mendelian randomization study.

ABSTRACT:

Objective

To explore the causal relationship between cystatin C levels and different stages of diabetic retinopathy through Mendelian randomization (MR).

Methods

The MRC Integrative Epidemiology Unit provided the Genome-wide association studies (GWAS) data related to cystatin C (exposure). GWAS data for outcomes [DR, proliferative diabetic retinopathy (PDR), severe non-proliferative background diabetic retinopathy (SNPBDR)] were sourced from the FinnGen. Adopted Inverse Variance Weighting (IVW), MR-Egger regression MR-PRESSO, Weighted Median, Constrained Maximum Likelihood and Model Averaging (cML-MA), Weighted model, Radial MR, and MR-Lasso to estimate the causal relationship between cystatin C and diabetic retinopathy. We conducted multivariable MR analysis to evaluate the

SUBMITTER: Ruan Y 

PROVIDER: S-EPMC11527803 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature