Antimalarial efficacy of <i>Duttaphrynus melanostictus</i> skin extract via inhibition of <i>Plasmodium falciparum</i> Na⁺/H⁺ ATPase.

ABSTRACT: Malaria remains a major health issue worldwide that affects many people, particularly in developing nations. Since, the malarial parasite has developed resistance against nearly every antimalarial drug now in use, it is imperative to search for novel antimalarial medications. Toxins produced by skin glands of toads have been shown to possess antiparasitic properties against a variety of protozoan parasites because of the bufadienolides they contain. Even though several studies have been conducted to show that toad skin secretions have antimalarial properties, very little information is known about the precise mechanism by which they work against Plasmodium infection. Thus, the goal of this study was to evaluate the antiplasmodial activity of crude skin extracts from Common Asian Toa

SUBMITTER: Bagwe AD 

PROVIDER: S-EPMC11527857 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature